For men's and women's fertility.
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Bibliographic references of the studies

  1. De Lamirande E. Gagnon C. Impact of reactive oxygen species on spermatozoa: a balancing act between beneficial and detrimentd effects.
  2. Agarwal et al., Role of reactive oxygen species in the pathophysiology of human reproduction. FERTILITY AND STERle VOL 79, NO. 4, APRIL 2003
  3. Thonneau P, Marchand S. Tallec A. Ferial ML, Ducot B, Lansac J, et al. Incidence and main causes of infertility in a resident population (1 ,850,000) of three French regions (1988-1989).
  4. Shanna RK et al. Role of reactive oxygen species in male infertility. Urology 1996;48:835-850.
  5. Shen HM, Chia SE, Ong CN. Evaluation of oxidative DNA damage in human sperm and its association with male infertility. J Androl 1999; 20:718-723
  6. Aitken RJ, De luliis GN. Finnie JM. Hedges A, McLachlan RI. Analysis of the relationships between oxidative stress, DNA damage and sperm vitality in a patient population: development of diagnostic criteria. Hum Reprod 2010;25:2415-2426.
  7. Lewis SEM, Boyle PM, McKinney KA, Young IS, Thompson W.
  8. Total antioxidant capacity of seminal plasma is different in fertile and infertile men. Fertil Steril 1995;64:868-70.
  9. Jones R. Mann T, Sherins RJ. Peroxidative breakdown of phospholipids in human spermatozoa: sperrnicidal effects of fatty acid peroxides and protective acton of seminal plasma. Fertil Steril 1979;31:531-537.
  10. Aitken RJ. A free radical theory of male infertility. Reprod Fertil Dev 1994;6z19-24.
  11. Sawyer DE, Mercer BG. Wiklendt AM. Aitken RJ. Analysis of gene-specific DNA damage and single-strand DNA breaks induced by pro-oxidant treatment of human spermatozoa in vitro. Mutat Res 2003;529:21-34.
  12. Kemal Duru N. Morshedi M, Oehninger 8. Effects of hydrogen peroxide on DNA and plasma membrane integrity of human spermatozoa. Fertil Steril 2000;74:1200-1207.
  13. Aitken & Clarkson, 1987; Aitken et al., 1989; Sharma & Agarwal, 1996; Sikka. 2001
  14. AganNal et al.. 2003
  15. Aganrval, A.: Role of antioxidants in treatment of male infertility. Reprod. Biomed. Online, 8. 616-627, 2004.
  16. Thiele, J.J., Freisleben. H.J., Fuchs, J., and Ochsendorf. FR: Ascorbic acid and urate in human seminal plasma: detection and interrelationship with chemiluminescence’s in washed semen. Hum. Reprod., 10, 110-115, 1995.
  17. Thiele, J.J., Freisleben, H.J., Fuchs, J.. and Ochsendorf, FR: Ascorbic acid and urate in human seminal plasma: detection and interrelationship with chemiluminescence’s in v.7 Thed semen. Hum. Reprod, 10, 1 10-1 15, 1995.
  18. Mostafa. T.. Tawadrous. (3., Roaia, M.M., Amer, M.K., Kader, R.A., and Aziz, A.: Effect of cigarette smoking on seminal plasma ascorbic acid in infertile and fertile males. Andrologia, 38, 221-224, 2006
  19. Dawson. E.B., Harris. W.A., Rankin, W.E., Charpentier. LA, and McGanity, W.J.: Effect of ascorbic acid on male fertility. Ann. NY Acad. Sci., 498, 312-323, 1987.
  20. Fraga, C.G., Motchnik, P.A., Shigenaga, M.K., Helbock, H.J.. Jacob. RA, and Ames. B.N.: Ascorbic acid protects against endogenous oxidative DNA damage in human sperm. Proc. Natl. Acad. Sci.. 88, 11003-11006, 1991.
  21. Wong WY, Merkus HM. Thomas CM, Menkveld R, Zielhuis GA and Steegers-Theunissen RP (2002) Effects of folic acid and zinc sulfate on male factor subfertility: a double-blind. randomized. placebo-controlled trial. Fertil Steril 77.491-498.
  22. Attaran M, Pasqualotto E. Falcone T, Goldberg JM, Miller KF. Agarwal A, et al. The effect of follicular fluid reactive oxygen species on the outcome of in vitro fertilization. Int J Fertil Worn Med 2000;45: 314-20.
  23. Jozwik M. Wolczynski S, Szamatowicz M. Oxidative stress markers in preovulatory follicular fluid in humans. Mol Hum Reprod 1999;5: 409-13.
  24. Curtis P. Lindsay P, Jackson AE. Shaw RW. Adverse effects on sperm movement characteristic in women with minimal and mild endometriosis. Br JObstet Gynaecol 1 993:1 00:1 65-9.
  25. Oak MK, C .‘Jntler EN. Wiliams CA. Elstein M. Sperm survival studies in peritoneal fluid from infertile women with endometriosis and unexplained infertility. Clin Reprod Fertil 1985;3z297-303.
  26. Morcos RN. Gibbons WE. Findley WE. Effect of peritoneal fluid on in vitro cleavage of 2-cell mouse embryos: possible role in infertility associated with endometriosis. Fertil Steril 1985;44:678-813.
  27. Bartmann AK, Romao GS, Ramos Eda S, Ferriani RA. Why do older women have poor implantation rates? A possible role of the mitochondria. J Assist Reprod Genet 2004;21:79-8§
  28. Wilding M, Di Matteo l... L. .;.‘e B. The maternal age effect: a hypothesis based on oxidative phosphorylation. Zygote 2005;13:317-233.
  29. Seifer DB, DeJesus V, Hubbard K. Mitochondrial deletions in luteinized granulosa cells as a function of age in women undergoing in vitro fertilization. Fertil Steril 2002;78:1046-8.
  30. Cohen J. Scott R. Alikani M. Schimmel T. Munne S, Levron J, et al. Ooplasmic transfer in mature human oocytes. Mol Hum Reprod 1998;4z269-80.
  31. Takeuchi T, Neri QV. Katagiri Y, Rosenwaks Z. Palermo GD. Effect of treating induced mitochondrial damage on embryonic development and epigenesis. Biol Reprod 2005;72:584-92.
  32. Bentinger M, Brismar K. Dallner G. The antioxidant role of coenzyme Q. Mitochondrion 2007;(7 Suppl):S41-50.
  33. Noia G. Romano D, De Santis M. Mariorenzi S, Caruso A, Mancuso S. Coenzyme 010 fetal plasma levels. Fetal Diagn Ther 1998;13:127-30.
  34. Bentinger M. Tekle M, Brismar K. Chojnacki T. Swiezewska E. Dallner G. Stimulation of coenzyme 0 synthesis. Biofactors 2008;32:99-111.
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  38. Bergmann J, et al. The efficacy of the complex medication Phyto-Hypophyson L in female. hormone-related sterility. A randomized, placebo-controlled clinical double-blind study. WWW 2000 Aug; 7(4):190-9.
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  40. Brickell. 0.. ed. Royal Horticultural Society encyclopedia of plants and flowers. 1989, Dorling Kindersley: London
  41. Blumenthal. M., German Federal Institute for Dmgs and Medical Devices. Commission E. Herbal Medicine: expanded Commission E monographs. lst ed. 2000. Newton, Mass.: Integrative Medicine Communications.
  42. Roemheld-Hamm. 8., Chasteberry. Am Fam Physician, 2005. 72(5): p. 821 -4.
  43. Liu, J., et al., Evaluation of estrogenic activity of plant extracts for the potential treatrnent of menopausal symptoms. J Agric Food Chem. 2001. 49(5): p. 2472-9.
  44. Dixon-Shanies, D. and N. Shaikh, Growth inhibition of human breast cancer cells by herbs and phytoestrogens. Oncol Rep, 1999. 8: p. 1383-7.
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  46. McArdle HJ, Ashworth CJ. Micronutrients in fetal growth and development. Br Med Bull 1999;55:499-510.
  47. Ashworth CJ, Antipatis C. Micronutrient programming of development throughout gestation. Reproduction 2001 ;122:527-535.
  48. Chavarro JE, Rich-Edwards JW, Rosner BA, Willett WC. Iron intake and risk of ovulatory infertility. Obstet Gynecol 2006;108:1145-1152.
  49. Ebisch IMW. Thomas CMG. Peters WHM. Braat DDM. Steegers-
    Theunissen RPM. The importance of folate. zinc and 60 Battaglia, C.. et al. Adjuvant L-Arginine treatment for in-vitro antioxidants in the pathogenesis and prevention of subfartility. Hum fertilization in poor responder patients. Human Reproduction vol. 14 no.7

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